Alpha-lipoic Acid

Alpha-lipoic acid (ALA) is a naturally occurring compound that is synthesized in small amounts by the human body. ALA works together with other vitamins C and E. It is important for growth, helps to prevent cell damage, and helps the body rid itself of harmful substances.

ALA contains an asymmetric carbon, meaning there are two possible optical isomers (r-ALA and s-ALA). Some evidence has suggested that r-ALA is more easily absorbed by the body.

Several studies show that ALA may help reduce pain, burning, itching, tingling, and numbness in people who have nerve damage (called peripheral neuropathy) caused by diabetes. ALA has been used for this purpose in Europe for years. Other studies have shown that ALA speeds the removal of glucose from the blood of people with diabetes.

ALA also relieves stress on the liver and helps rid the body of toxins, and it has been thought to aid in the treatment of hepatitis.

ALA can easily pass into the brain and has protective effects on brain and nerve tissue and shows potential as a treatment for stroke and other brain disorders involving free radical damage.

Since ALA has been associated with improved blood sugar control, people with diabetes should monitor their blood sugar levels carefully when taking this supplement in order to avoid hypoglycemia (low blood sugar).

Please note that the evidence on ALA for type 2 diabetes and obesity is limited. A few small studies in animals and humans have shown hints of benefits.

Others have suggested that ALA can be used as an aid for those trying to decrease insulin resistance and/or lose weight. It has also been proposed to be beneficial before high carbohydrate or “cheat” meals for those on a diet.

For general antioxidant support, the recommended dose of ALA is 20mg to 50mg daily.